Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment

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dc.contributor.authorKihara, Jimmy H.
dc.contributor.authorNjagi, Eliud N.
dc.contributor.authorKenya, Eucharia U.
dc.contributor.authorMwanje, Marium T.
dc.contributor.authorOdek, Adel E.
dc.contributor.authorvan Dam, Govert
dc.contributor.authorKahama, Anthony I.
dc.contributor.authorOuma, John
dc.date.accessioned2015-07-15T12:52:46Z
dc.date.available2015-07-15T12:52:46Z
dc.date.issued2009-08
dc.descriptiondoi: 10.1016/j.trstmh.2009.04.021.en_US
dc.description.abstractSchistosoma haematobium soluble egg antigen (SEA) secreted in urine can be assayed to determine egg tissue load and hence morbidity in infected individuals. A cohort of 158 infected children aged 4-18 years was followed-up for 33 days pre and post treatment with a single dose of praziquantel. There was a significant difference in the prevalence of S. haematobium between males and females (P < 0.05). There were also significant differences in egg counts between age group < or = 5 years compared with 6-8 years, 9-11 years and 12-14 years, and age group > or = 15 years compared with 6-8 years, 9-11 years and 12-14 years (P < 0.05). Comparison of SEA among age groups indicated a significant difference between age group < or = 5 years compared with 9-11 years, 12-14 years and > or = 15 years, and age group > or = 15 years compared with 9-11 years and 12-14 years (P < 0.05). There was a statistically significant correlation between levels of SEA and egg output (r2=0.961, P=0.010). These results are useful in the development of a SEA-based dipstick assay for field diagnosis of urinary schistosomiasis.en_US
dc.identifier.citationTrans. of the Royal Soc. of Trop. Med. and Hygiene: vol.103 pp:1024—1030en_US
dc.identifier.urihttp://hdl.handle.net/123456789/213
dc.language.isoenen_US
dc.subjectSchistosoma haematobiumen_US
dc.subjecturinary schistosomiasisen_US
dc.titleUrinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatmenten_US
dc.typeArticleen_US
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