Browsing by Author "Wu, Jing"

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    Low-dose combined exposure of nanoparticles and heavy metal compared with PM2.5 in human myocardial AC16 cells
    (Springer, 2017-12) Feng, L.; Yang, X.; Asweto, Collins O.; Wu, Jing; Zhang, Y; Hu, H.; Shi, Y.; Duan, Junchao; Sun, Z.
    The co-exposure toxicity mechanism of ultrafine particles and pollutants on human cardiovascular system are still unclear. In this study, the combined effects of silica nanoparticles (SiNPs) and/or carbon black nanoparticles (CBNPs) with Pb(AC)2 compared with particulate matter (PM)2.5 were investigated in human myocardial cells (AC16). Our study detected three different combinations of SiNPs and Pb(AC)2, CBNPs and Pb(AC)2, and SiNPs and CBNPs compared with PM2.5 at low-dose exposure. Using PM2.5 as positive control, our results suggested that the combination of SiNPs and Pb(AC)2/CBNPs could increase the production of reactive oxygen species (ROS), lactate dehydrogenase leakage (LDH), and malondialdehyde (MDA) and decrease the activities of superoxide dismutase (SOD) and glutathione (GSH); induce inflammation by the upregulation of protein CRP and TNF-α, and apoptosis by the upregulation of protein caspase-3, caspase-9, and Bax while the downregulation of protein Bcl-2; and trigger G2/M phase arrest by the upregulation of protein Chk2 and downregulation of protein Cdc2 and cyclin B1. In addition, the combination of CBNPs and Pb(AC)2 induced a significant increase in MDA and reduced the activities of ROS, LDH, SOD, and GSH, with G1/S phase arrest via upregulation of Chk1 and downregulation of CDK6 and cyclin D1. Our data suggested that the additive interaction and synergistic interaction are the major interaction in co-exposure system, and PM2.5 could trigger more severe oxidative stress, G2/M arrest, and apoptosis than either co-exposure or single exposure.
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    Performance Study of Multi-Path in VANETs and Their Impact on Routing Protocols
    (Scientific Research Publishing, 2011-07) Wu, Jing; Wang, Yuhao
    Modeling complicated vehicular traffic behavior and analyzing effects on the communication performance of routing protocols taken by environmental factors have been a challenging task for the past several years. In this paper, we study the performance of multi-path routing protocol. Then, we investigate both multi-path and single-path routing protocol and analyze characteristics such as network connectivity, vehicle-node density etc. To better understand this phenomenon, we use mobility model with different parameters and evaluate the performance of routing protocols (Ad-hoc On-Demand Distance Vector and Ad-hoc On-demand Multipath Distance Vector routing protocols) through NS2 platform. The simulation results show the significance of multi-path on the throughput, loss and average delay of VANETs. The results of this paper may be used to study designing route protocols and applications of VANET.