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Effect of SP600125 on proliferation of embryonic stem cell
(Scientific Research Publishing, 2013-04)
SP600125 is an inhibitor of c-Jun NH2-terminal kinase (JNK), which plays a fundamental role in regulating animal development. Using SP600125 to deal with the mouse embryonic stem cells, it is revealed that the number of ...
TLR5 involvement in attenuated IL-8 production in nuclear decorin silenced oral mucosal dysplastic keratinocytes and squamous cell carcinoma
(Scientific Research Publishing, 2013-10)
Head and neck cancer is one of the most prevalent cancers in the world. Roughly half of these malignancies originate from oral mucosa and constitute Oral squamous cell carcinomas. Despite many advances in diagnostic and ...
Identification of a SSR marker (TOM-144) linked to Fusarium wilt resistance in Solanum lycopersicum
(Scientific Research Publishing, 2013-10)
With the discovery of molecular markers and marker assisted selection technology, the research has entered into a new era and has made it possible to develop new and more informative PCR-based markers, including SSR, and ...
Cyclosporin A inhibits the growth of neonatal MHC-expressing myotubes independent of NFATc1 and NFATc3 in the mechanically overloaded soleus muscle of mice
(Scientific Research Publishing, 2011-04)
ABSTRACT The molecular signaling pathway linked to hyper-trophy of the anti-gravity/postural soleus muscle af-ter mechanical overloading has not been identified. Using Western blot and immunohistochemical analy-ses, we ...
Cytosolic chaperonin CCT possesses GTPase activity
(Scientific Research Publishing, 2011-10)
Cytosolic chaperonin CCT (also known as TRiC) is a hetero-oligomeric cage-like molecular chaperone that assists in protein folding by ATPase cycle-dependent conformational changes. However, role of the nucleo-tide binding ...
The molecular regulatory effect of intracerebroventricular thymulin on endotoxin-mediated NF-kB nuclear translocation and activation in vivo
(Scientific Research Publishing, 2013-01)
The nuclear factor-kB (NF-kB) is one member of a ubiquitously expressed family of Rel-related transcription factors that serve as critical regulators of proinflammatory genes. The immunomodulatory potential of thymulin and ...
The origin of biological information and programmed protein synthesis
(Scientific Research Publishing, 2013-10)
Biological information is one of the most important characteristics of life, and it enables life to evolve to higher complexity and adapt to the environment by mutation and natural selection. However, the origin of this ...
An engineered Phlebia radiata manganese peroxidase: expression, refolding, purification and preliminary characterization
(Scientific Research Publishing, 2012-10)
Manganese peroxidases (MnPs) are interesting enzymes in protein engineering, aimed at maximizing industrial bioprocesses such as lignin degradation and biofuel production. cDNA of the secreted short-type of MnP from Phlebia ...
Tandem repetitions in transcriptomes of some Solanaceae species
(Scientific Research Publishing, 2012-04)
Characterization of occurrence, density and motif sequence of tandem repeats in the transcribed regions is helpful in understanding the functional significance of these repeats in the modern genomes. We analyzed tandem ...
Diagnostic and prognostic value of plasma level of microRNA-92a in acute myeloid leukemia
(Scientific Research Publishing, 2014-01)
Background: MicroRNAs (miRNAs) are short noncoding RNAs of ~21 to 23 nucleotides in length that post-transcriptionally regulate mRNA expression. Highthroughput methodologies have shown deregulated miRNA expression in an ...