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Mutation EthAW21R confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
(Dove Press, 2018-06)
Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis
(TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic
information on the modes of sensitivity and resistance ...
Advances in the development of molecular genetic tools for Mycobacterium tuberculosis
(Elsevier, 2018-07)
Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen
owing to its complex physiological characteristics and development of drug resistance. Several molecular
genetic ...
Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach
(American Society for Microbiology, 2020-02)
Mycobacterium abscessus is intrinsically resistant to most antimicrobial
agents. The emerging infections caused by M. abscessus and the lack of effective
treatment call for rapid attention. Here, we intended to construct ...