Anti-plasmodial Activity of Some Kenyan Medicinal Plant Extracts Singly and in Combination with Chloroquine

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dc.contributor.authorMuregi, F.W.
dc.contributor.authorChhabra, S.C.
dc.contributor.authorNjagi, Eliud N.
dc.contributor.authorLang’at, C.
dc.contributor.authorNjue, Wilson N.
dc.contributor.authorOrago, A.S.
dc.contributor.authorOmar, S.A.
dc.contributor.authorNdiege, I.O.
dc.date.accessioned2015-07-27T10:22:11Z
dc.date.available2015-07-27T10:22:11Z
dc.date.issued2004
dc.description.abstractSixty organic and aqueous extracts of eleven plants used for the control of malaria by local communities in Kisii District, Kenya were screened for in vitro anti-plasmodial activity. The plants selection was based on existing ethnobotanical information and interviews with local communities. The extracts were tested against chloroquine sensitive and resistant laboratory adapted strains of Plasmodium falciparum. The study revealed that 63.6% of the plants were active (IC50 ≤ 100 μg/mL). Extracts of four plants, Ekebergia capensis, Stephania abyssinica, Ajuga remota and Clerodendrum myricoides gave IC50 values below 30 μg/mL against both chloroquine sensitive and resistant P. falciparum strains. Combination of extracts of E. capensis and C. myricoides with chloroquine against the multi-drug resistant P. falciparum isolate (V1/S) revealed synergistic effect. The plants which showed activity may be useful as sources for novel anti-plasmodial compounds.en_US
dc.identifier.citationPhytotherapy Research Phytother. Res. 18, 379–384 (2004)en_US
dc.identifier.urihttp://hdl.handle.net/123456789/328
dc.language.isoenen_US
dc.publisherWiley InterScienceen_US
dc.subjectplant extractsen_US
dc.subjectanti-plasmodialen_US
dc.subjectethno-botanyen_US
dc.subjectsynergismen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectAcacia hockiien_US
dc.subjectAjuga remotaen_US
dc.subjectClerodendrum myricoidesen_US
dc.subjectCucumis figareien_US
dc.subjectEkebergia capensisen_US
dc.subjectLeonotis mollissimaen_US
dc.subjectLeucas calostachysen_US
dc.subjectMelia azedarachen_US
dc.subjectParinari curatellifoliaen_US
dc.subjectSenna didymobotryaen_US
dc.subjectStephania abyssinicaen_US
dc.titleAnti-plasmodial Activity of Some Kenyan Medicinal Plant Extracts Singly and in Combination with Chloroquineen_US
dc.typeArticleen_US
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