Anti-inflammatory norhopanes from the root bark of Fagaropsis angolensis (Engl.) H.M.Gardner

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dc.contributor.authorNyaga, Justine M.
dc.contributor.authorMukavia, Justus
dc.contributor.authorOmosa, Leonidah Kerubo
dc.contributor.authorNgnitedemb, Vaderament Nchiozem
dc.contributor.authorOmoled, Ruth
dc.contributor.authorBitchagnoc, Gabin Thierry M.
dc.contributor.authorSpitellere, Michael
dc.date.accessioned2021-01-26T10:28:49Z
dc.date.available2021-01-26T10:28:49Z
dc.date.issued2020-06-17
dc.description.abstractTwo new norhopane derivatives namely 3β,6β,22-trihydroxy-7β,11α-di[(4-hydroxybenzoyl)oxy]-21αH-24- norhopa-4(23)-ene (1) and 3β,6β,22-trihydroxy-7β-[(4-hydroxybenzoyl)oxy]-21αH-24-norhopa-4(23)-ene (2) together with two previously reported compounds, including a norhopane, 3β,6β,11α-trihydroxy-7β-[(4-hydroxybenzoyl) oxy]-24-norhopa-4(23),17(21)-diene (3) and a norneohopane, (21αH)-24-norneohopa-4(23), 22(29)-diene-3β,6β,7β-triol 7-caffeate (4) were isolated from the root bark of Fagaropsis angolensis. Elucidation of their structures was achieved by spectroscopic (NMR, IR and UV) and spectrometric (HRESIMS) data and by comparison of these data with those of related compounds in the literature. Compounds 1–4 were evaluated for their anti-inflammatory activity by measuring the levels of cytokines, IL-1β, IL-2, GM-CSF and TNF-α in lipopolysaccharide (LPS) stimulated peripheral blood mononuclear cells (PBMC). All tested compounds decreased secretion of IL-1β and TNF-α. Compounds 2 and 4 caused significant decrease of the production of IL-2, GM-CSF and TNF-α compared to the reference drug, ibuprofen. These findings showed that the root barks of F. angolensis are rich source of norhopane derivatives and further provide a scientific rationale of using this plant in Kenyan folk medicine to relieve pain.en_US
dc.identifier.uriwww.elsevier.com/locate/fitote
dc.identifier.urihttps://doi.org/10.1016/j.fitote.2020.104690
dc.identifier.urihttp://repository.embuni.ac.ke/handle/embuni/3698
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectFagaropsis angolensisen_US
dc.subjectRutaceaeen_US
dc.subjectNorhopanesen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectStructure elucidationen_US
dc.titleAnti-inflammatory norhopanes from the root bark of Fagaropsis angolensis (Engl.) H.M.Gardneren_US
dc.typeArticleen_US
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