Hypoglycemic Activity of Some Kenyan Plants Traditionally used to Manage Diabetes Mellitus in Eastern Province

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dc.contributor.authorPiero, Ngugi M.
dc.contributor.authorJoan, Murugi N.
dc.contributor.authorKibiti, Cromwell M.
dc.contributor.authorNgeranwa, Joseph
dc.contributor.authorNjue, Wilson N.
dc.contributor.authorMaina, Daniel N.
dc.contributor.authorGathumbi, Peter
dc.contributor.authorNjagi, Eliud N.
dc.date.accessioned2015-07-27T12:52:31Z
dc.date.available2015-07-27T12:52:31Z
dc.date.issued2011
dc.description.abstractIn this study five aqueous extracts; Bidens pilosa, Strychnos henningsii, Aspilia pluriseta, Catha edulis and Erythrina abyssinica were screened for anti-diabetic activity and their in vivo safety evaluated. The anti-diabetic activity was assessed by intraperitoneally injecting varying doses of aqueous extracts of the five plants into alloxanised mice. Toxicity was determined by injecting normal mice with 450mg of the plant extract / kg body weight and observing the effects of the extracts on histology of various organs. All the extracts showed hypoglycaemic activity. At high doses, some plants proved to be highly toxic, mildly toxic and others were safe. This study has established that the five bioactive plants can be safely used in the management of diabetes.en_US
dc.identifier.citationPiero et al. J Diabetes Metab 2011, 2:8en_US
dc.identifier.issn2155-6156
dc.identifier.urihttp://hdl.handle.net/123456789/338
dc.language.isoenen_US
dc.subjectAnti-diabetic activityen_US
dc.subjectin vivo toxicityen_US
dc.subjectHistologyen_US
dc.subjectAlloxanised miceen_US
dc.titleHypoglycemic Activity of Some Kenyan Plants Traditionally used to Manage Diabetes Mellitus in Eastern Provinceen_US
dc.typeArticleen_US
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