Comprehensive gene and microRNA expression profiling on cardiovascular system in zebrafish co exposured of SiNPs and MeHg

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dc.contributor.authorHu, H.
dc.contributor.authorShi, Y.
dc.contributor.authorZhang, Y.
dc.contributor.authorWu, J.
dc.contributor.authorAsweto, Collins O.
dc.contributor.authorFeng, L.
dc.contributor.authorYang, X.
dc.contributor.authorDuan, J.
dc.contributor.authorSun, Z.
dc.date.accessioned2018-10-12T12:54:58Z
dc.date.available2018-10-12T12:54:58Z
dc.date.issued2017-12
dc.description.abstractAir pollution has been shown to increase cardiovascular diseases. However, little attention has been paid to the combined effects of PM and air pollutants on the cardiovascular system. To explore this, a high-throughput sequencing technology was used to determine combined effects of silica nanoparticles (SiNPs) and MeHg in zebrafish. Our study demonstrated that SiNPs and MeHg co-exposure could cause significant changes in mRNA and miRNA expression patterns in zebrafish. The differentially expressed (DE) genes in profiles 17 and 26 of STC analysis suggest that SiNPs and MeHg co-exposure had more proinflammatory and cardiovascular toxicity in zebrafish than single exposure. Major gene functions associated with cardiovascular system in the co-exposed zebrafish were discerned from the dynamic-gene-network, including stxbp1a, celf4, ahr1b and bai2. In addition, the prominently expressed pathway of cardiac muscle contraction was targeted by 3 DE miRNAs identified by the miRNA-pathway-network (dre-miR-7147, dre-miR-26a and dre-miR-375), which included 23 DE genes. This study presents a global view of the combined SiNPs and MeHg toxicity on the dynamic expression of both mRNAs and miRNAs in zebrafish, and could serve as fundamental research clues for future studies, especially on cardiovascular system toxicity.en_US
dc.identifier.citationSci. Total Environ. 607-608(17), 795-805en_US
dc.identifier.uriDOI: 10.1016/j.scitotenv.2017.07.036
dc.identifier.urihttp://hdl.handle.net/123456789/2093
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectCardiovascular systemen_US
dc.subjectCombined toxicityen_US
dc.subjectMeHgen_US
dc.subjectSiNPsen_US
dc.subjectTranscriptional analysisen_US
dc.titleComprehensive gene and microRNA expression profiling on cardiovascular system in zebrafish co exposured of SiNPs and MeHgen_US
dc.typeArticleen_US
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