Super-Enhancement and Control of Amh Expression

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dc.contributor.authorDresser, David W.
dc.date.accessioned2016-10-17T07:54:11Z
dc.date.available2016-10-17T07:54:11Z
dc.date.issued2016-07
dc.description.abstractIn previous work it was shown that mutation of site 1 in the downstream enhancer sequence (DE) led to ablation of enhancement. Mutation of the Wilms tumour factor element (Wt), situated in the Amh promoter between the tata box and the start of translation (TSS), also led to ablation of enhancement. This suggested that these sites may be the anchor points for a specific duplex factor bridging remote DNA elements to the promoter. Mutation analysis of the DNA sequence between sections 1 and 2 of DE was carried out by site directed mutagenesis. It is reported here that site 4 lying between DE1 and DE2, plays a key role in controlling the level of enhancement.en_US
dc.identifier.citationAmerican Journal of Molecular Biology, 2016, 6, 117-123en_US
dc.identifier.urihttp://dx.doi.org/10.4236/ajmb.2016.63012
dc.identifier.urihttp://hdl.handle.net/123456789/956
dc.language.isoenen_US
dc.publisherScientific Research Publishingen_US
dc.subjectEnhancementen_US
dc.subjectSuper-Enhancementen_US
dc.subjectAmhen_US
dc.subjectGene Expressionen_US
dc.titleSuper-Enhancement and Control of Amh Expressionen_US
dc.typeArticleen_US
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