Abstract:
The majority of bacteria responsible for Lower Respiratory Tract Infections (LRTIs) are multiresistant to antibiotics. The objectives of this study are to describe the antibiotic resistance of these bacteria in LRTIs and to describe the factors associated with these infections. It is a prospective study of 54 respiratory samples of patients with LRTIs for a period of six months from July 2019 to December 2019 in the laboratory of the University Hospital of Befelatanana Antananarivo. The microbiological results showed 12 (22%) isolates of nonfermenting gram-negative bacilli, 10 (19%) isolates of streptococci and 6 (11%) isolates of enterobacteria. Regarding the isolates of nonfermenting gram-negative bacilli, the antibiotic resistance, varies from 42% (amikacin) to 100% (cotrimoxazole). Concerning the isolates of streptococci, it varies from 0% (vancomycin) to 80% (penicillin G). And the antibiotic resistance of the isolates of enterobacteria varies from 0% (imipenem and amikacin) to 100% (amoxicillin). Concerning the associated factors, subjects aged 40 and over (58.6%) (p = 0.84; NS), men (71.4%) (p = 0.01) and subjects hospitalized in intensive care units (70.3%) (p = 0.004) are the most affected by LRTIs. In brief, the knowledge of antibiotic resistance of bacteria responsible for LRTIs allows better patient management.
