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Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies.
(Elsevier, 2017-12)
Silica nanoparticles (SiNPs) have been found to pass through biological barriers and get distributed in the human body. They induce cell apoptosis via various mechanisms in body organs. To understand these mechanisms, we ...
Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2. 5 in human myocardial cells.
(2017-04)
Air pollution has been a major environment-related health threat. Most of the studies on PM2.5 toxicity have verified on the cardiovascular system and endothelial cells. However, researches on PM2.5-induced myocardial-related ...
Gene profiles to characterize the combined toxicity induced by low level co-exposure of silica nanoparticles and benzo[a]pyrene using whole genome microarrays in zebrafish embryos.
(Elsevier, 2018-07)
Several studies have suggested that air pollutants combine exposure have greater adverse effects. However, limited studies were available on the combined toxicity of silica nanoparticles (SiNPs) and benzo[a]pyrene (B[a]P). ...
Telomere Length and Accelerated Biological Aging in the China Suboptimal Health Cohort: A Case-Control Study
(Mary Ann Liebert, Inc, 2017-06)
Suboptimal health status (SHS) has been linked to cardiovascular risk factors, psychosocial stress, and unhealthy
lifestyle. These factors also contribute to the shortening of telomere length (TL). A case–control study
was ...
Fine particulate matter induces vascular endothelial activation 4 via IL-6 dependent JAK1/STAT3 signaling pathway. Toxicol.
(2016-04)
Exposure to PM2.5 has been strongly linked to endothelial dysfunction. However, the underlying mechanism
of PM2.5 on the vascular endothelial function is poorly understood. This study examined the toxic
effect and ...
1H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation
(Elsevier, 2017-07)
Systemic metabolic effects and toxicity mechanisms of ambient fine particulate matter (PM2.5) remain uncertain. In order to investigate the mechanisms in PM2.5 toxicity, we explored the endogenous metabolic changes and ...
Gene expression profiles and bioinformatics analysis of human umbilical vein endothelial cells exposed to PM2.5
(Elsevier, 2017-05)
Cardiovascular system is demonstrated the main target of PM2.5 and the objective of this study was to explore the toxic effect and molecular mechanisms caused by PM2.5 in primary human umbilical vein endothelial cells ...
Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epithelial BEAS-2B cells
(SpringerLink, 2016-11)
Both ultrafine particles (UFP) and polycyclic aromatic hydrocarbons (PAHs) are widely present in the environment, thus increasing their chances of exposure to human in the daily life. However, the study on the combined ...
The Malaysian health care system: Ecology, plans, and reforms.
(2016-01)
Malaysia is on its way to achieving developed nation status in the next 4 years. Currently, Malaysia is on track for three Millennium Development Goals (MDG1, MDG4, and MDG7). The maternal mortality rate, infant mortality ...
Utilization of ANC and PNC Services in Nepal: A Multivariate Analysis Based on Nepal Demographic Health Survey 2001 and 2006.
(Science Publishing Group, 2015-10-12)
Background: Maternal Mortality is a public health problem in Nepal, which was highest in 1990 among the South
Asian countries. Associated factors of maternal mortality are various; among them maternal health services such ...