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Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells
(MDPI, 2017-03)
Particulate matter (PM) such as ultrafine particulate matter (UFP) and the organic
compound pollutants such as polycyclic aromatic hydrocarbon (PAH) are widespread in the
environment. UFP and PAH are present in the air, ...
Integration of community health workers into health systems in developing countries: Opportunities and challenges
(Systematic Review, 2016-01)
Background: Developing countries have the potential to reach vulnerable and underserved
populations marginalized by the country’s health care systems by way of community health workers
(CHWs). It is imperative that health ...
Maternal Autonomy, Distance to Health Care Facility and ANC Attendance Findings from Madiany Division of Siaya County, Kenya
(Science and Education Publishing, 2014-08)
Half a million women die annually from pregnancy related causes. In Kenya, maternal mortality ratio (MMR) remains high in spite of great efforts to improve maternal health care. We studied some factors linked to maternity ...
Women Empowerment and Skilled Attendance/Facility Delivery in a Rural Community of Western Kenya
(2014-04)
It is estimated that over 500,000 women die annually due to maternity complications, majority occur in the developing countries. In Kenya, maternal mortality ratio still remains high despite increased maternal health ...
Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies.
(Elsevier, 2017-12)
Silica nanoparticles (SiNPs) have been found to pass through biological barriers and get distributed in the human body. They induce cell apoptosis via various mechanisms in body organs. To understand these mechanisms, we ...
Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2. 5 in human myocardial cells.
(2017-04)
Air pollution has been a major environment-related health threat. Most of the studies on PM2.5 toxicity have verified on the cardiovascular system and endothelial cells. However, researches on PM2.5-induced myocardial-related ...
Telomere Length and Accelerated Biological Aging in the China Suboptimal Health Cohort: A Case-Control Study
(Mary Ann Liebert, Inc, 2017-06)
Suboptimal health status (SHS) has been linked to cardiovascular risk factors, psychosocial stress, and unhealthy
lifestyle. These factors also contribute to the shortening of telomere length (TL). A case–control study
was ...
Fine particulate matter induces vascular endothelial activation 4 via IL-6 dependent JAK1/STAT3 signaling pathway. Toxicol.
(2016-04)
Exposure to PM2.5 has been strongly linked to endothelial dysfunction. However, the underlying mechanism
of PM2.5 on the vascular endothelial function is poorly understood. This study examined the toxic
effect and ...
1H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation
(Elsevier, 2017-07)
Systemic metabolic effects and toxicity mechanisms of ambient fine particulate matter (PM2.5) remain uncertain. In order to investigate the mechanisms in PM2.5 toxicity, we explored the endogenous metabolic changes and ...
Gene expression profiles and bioinformatics analysis of human umbilical vein endothelial cells exposed to PM2.5
(Elsevier, 2017-05)
Cardiovascular system is demonstrated the main target of PM2.5 and the objective of this study was to explore the toxic effect and molecular mechanisms caused by PM2.5 in primary human umbilical vein endothelial cells ...