Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease
Scanu, Angelo M.
Stafforini, Diana M.
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Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.