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dc.contributor.authorThompson, William A.
dc.contributor.authorWeltman, Joel K.
dc.date.accessioned2016-10-24T06:23:30Z
dc.date.available2016-10-24T06:23:30Z
dc.date.issued2012-01
dc.identifier.citationAmerican Journal of Molecular Biology, 2012, 2, 32-4en_US
dc.identifier.urihttp://dx.doi.org/10.4236/ajmb.2012.21004
dc.identifier.urihttp://hdl.handle.net/123456789/992
dc.description.abstractWe report a bioinformatic analysis of the datasets of sequences of all ten genes from the 2009 H1N1 influenza A pandemic in the state of Wisconsin. The gene with the greatest summed information entropy was found to be the hemagglutinin (HA) gene. Based upon the viral ID identifier of the HA gene sequence, the sequences of all of the genes were sorted into two subsets, depending upon whether the nucleotide occupying the position of maximum entropy, position 658 of the HA sequence, was either A or U. It was found that the information entropy (H) distributions of subsets differed significantly from each other, from H distributions of randomly generated subsets and from the H distributions of the complete datasets of each gene. Mutual information (MI) values facilitated identification of nine nucleotide positions, distributed over seven of the influenza genes, at which the nucleotide subsets were disjoint, or almost disjoint. Nucleotide frequencies at these nine positions were used to compute mutual information values that subsequently served as weighting factors for edges in a graph net-work. Seven of the nucleotide positions in the graph network are sites of synonymous mutations. Three of these sites of synonymous mutation are within a single gene, the M1 gene, which occupied the position of greatest graph centrality. It is proposed that these bioinformatic and network graph results may reflect alterations in M1-mediated viral packaging and exteriorization, known to be susceptible to synonymous mutations.en_US
dc.language.isoenen_US
dc.publisherScientific Research Publishingen_US
dc.subjectInfluenza Aen_US
dc.subjectH1N1en_US
dc.subjectBioinformaticsen_US
dc.subjectGenesen_US
dc.subjectPandemicen_US
dc.subjectEpidemicen_US
dc.subjectInformation Entropyen_US
dc.subjectMutualInFormationen_US
dc.subjectGraphen_US
dc.subjectNetworken_US
dc.subjectCentralityen_US
dc.subjectSubsetsen_US
dc.titleIntergenic subset organization within a set of geographically-defined viral sequences from the 2009 H1N1 influenza A pandemicen_US
dc.typeArticleen_US


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