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The ATPase activity of molecular chaperone HSP60 is inhibited by immunosuppressant mizoribine
(Scientific Research Publishing, 2012-04)
The molecular chaperone HSP60 is a chaperonin homolog of GroEL. We had previously shown that the immunosuppressant mizoribine is bound directly to HSP60 and inhibited its chaperone activity. However, the inhibitory mechanisms ...
Cytosolic chaperonin CCT possesses GTPase activity
(Scientific Research Publishing, 2011-10)
Cytosolic chaperonin CCT (also known as TRiC) is a hetero-oligomeric cage-like molecular chaperone that assists in protein folding by ATPase cycle-dependent conformational changes. However, role of the nucleo-tide binding ...