Browsing Articles: School of Nursing by Author "Asweto, Collins O."
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1H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation
Zhang, Y.; Hu, H.; Shi, Y.; Yang, X.; Cao, L.; Wu, J.; Asweto, Collins O.; Feng, L.; Duan, J.; Sun, Z. (Elsevier, 2017-07)Systemic metabolic effects and toxicity mechanisms of ambient fine particulate matter (PM2.5) remain uncertain. In order to investigate the mechanisms in PM2.5 toxicity, we explored the endogenous metabolic changes and ... -
Cardiovascular health risk posed by polycyclic aromatic hydrocarbon and ultrafine particles.
Asweto, Collins O. (2018-01)There is increased cardiovascular disease incidence attributed to ambient air pollution. It is estimated that ischaemic heart disease and stroke account for 80% of ambient air pollutionrelated early deaths. The most ... -
Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies.
Asweto, Collins O.; Wu, J.; Alzain, M. A.; Hu, H.; Andrea, S.; Feng, L.; Yeng, X.; Duan, J.; Sun, Z. (Elsevier, 2017-12)Silica nanoparticles (SiNPs) have been found to pass through biological barriers and get distributed in the human body. They induce cell apoptosis via various mechanisms in body organs. To understand these mechanisms, we ... -
Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epithelial BEAS-2B cells
Wu, J.; Shi, Y.; Asweto, Collins O.; Lin, F.; Xiaozhe, Y.; Zhang, Y.; Duan, J.; Sun, Z. (SpringerLink, 2016-11)Both ultrafine particles (UFP) and polycyclic aromatic hydrocarbons (PAHs) are widely present in the environment, thus increasing their chances of exposure to human in the daily life. However, the study on the combined ... -
Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells
Asweto, Collins O.; Jing, Wu; Hejing, Hu; Lin, Feng; Xiaozhe, Yang; Junchao, Duan; Zhiwei, Sun (MDPI, 2017-03)Particulate matter (PM) such as ultrafine particulate matter (UFP) and the organic compound pollutants such as polycyclic aromatic hydrocarbon (PAH) are widespread in the environment. UFP and PAH are present in the air, ... -
Comprehensive gene and microRNA expression profiling on cardiovascular system in zebrafish co exposured of SiNPs and MeHg
Hu, H.; Shi, Y.; Zhang, Y.; Wu, J.; Asweto, Collins O.; Feng, L.; Yang, X.; Duan, J.; Sun, Z. (Elsevier, 2017-12)Air pollution has been shown to increase cardiovascular diseases. However, little attention has been paid to the combined effects of PM and air pollutants on the cardiovascular system. To explore this, a high-throughput ... -
Does Breast Cancer Risk Awareness Motivate Personal Prevention Practices: Findings from a Community-based Assessment?
Ouma, J.; Olang’, S.; Asweto, Collins O.; Obago, I. T.; Kaseje, D. (2016-01)Breast cancer, is the leading cause of cancer specific mortality. But nearly 80% of the mortality is preventable by early diagnosis. We assessed knowledge and practice of breast cancer prevention by women in a rural community ... -
Early Mobilization and Physical Activity Improve Stroke Recovery: A Cohort Study of Stroke Inpatients in Kisumu County Referral Hospitals, Kenya
Ogolla, M. M.; Opemo, D. O.; Asweto, Collins O. (2016-01)Early mobilization in acute stroke care is highly recommended in a range of developed countries policy; however, in developing countries like Kenya, lack of evidence seems to hinder formulation and implementation of policy ... -
Effects of increased residential mobility and reduced public spaces Effects of increased residential mobility and reduced public spaces mobility in containing COVID-19 in Africa
Asweto, Collins O.; Onyango, Patrick O.; Alzain, Mohamed A; Wang, Wei (Global Reports, 2020-09)Background Background The rising COVID-19 crisis threatens to disproportionately hit African countries. As a result, most African governments have temporarily closed schools and non-essential businesses or banned ... -
Experience and Perceptions on Preterm Births among Women Attending ANC Clinic at Kisumu County Hospital, Kenya.
Samba, Benard O.; Ayodo, George; Amimo, Fred; Asweto, Collins O. (researchjournali, 2018-03)Preterm birth is one of the main causes of neonatal death, and it is now the second leading cause of death after pneumonia in children under the age of five. Kenya is estimated to have 12.3% preterm births and 22 neonatal ... -
Fine particle matters induce DNA damage and G2/M cell cycle arrest in human bronchial epithelial BEAS-2B cells
Wu, J.; Shi, Y.; Asweto, Collins O.; Feng, L.; Yang, X.; Zhang, Y.; Hu, H.; Duan, J.; Sun, Z. (SpringerLink, 2017-11)There is compelling evidence that exposure to particulate matter (PM) is linked to lung tumorigenesis. However, there is not enough experimental evidence to support the specific mechanisms of PM2.5-induced DNA damage and ... -
Fine particulate matter induces vascular endothelial activation 4 via IL-6 dependent JAK1/STAT3 signaling pathway. Toxicol.
Hu, H.; Wu, J.; Li, Q.; Asweto, Collins O.; Lin, F.; Xiaozhe, Y.; Duan, F.; Duan, J.; Sun, Z. (2016-04)Exposure to PM2.5 has been strongly linked to endothelial dysfunction. However, the underlying mechanism of PM2.5 on the vascular endothelial function is poorly understood. This study examined the toxic effect and ... -
Gene expression profiles and bioinformatics analysis of human umbilical vein endothelial cells exposed to PM2.5
Hu, H.; Asweto, Collins O.; Wu, J.; Shi, Y.; Feng, L.; Yang, X.; Liang, S.; Cao, L.; Duan, J.; Sun, Z. (Elsevier, 2017-05)Cardiovascular system is demonstrated the main target of PM2.5 and the objective of this study was to explore the toxic effect and molecular mechanisms caused by PM2.5 in primary human umbilical vein endothelial cells ... -
Gene profiles to characterize the combined toxicity induced by low level co-exposure of silica nanoparticles and benzo[a]pyrene using whole genome microarrays in zebrafish embryos.
Asweto, Collins O.; Hu, H; Liang, S.; Wang, L.; Liu, M.; Yang, H.; Duan, J.; Sun, Z. (Elsevier, 2018-07)Several studies have suggested that air pollutants combine exposure have greater adverse effects. However, limited studies were available on the combined toxicity of silica nanoparticles (SiNPs) and benzo[a]pyrene (B[a]P). ... -
Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2. 5 in human myocardial cells.
Feng, L.; Yang, X.; Asweto, Collins O.; Wu, J.; Zhang, Y.; Hu, H.; Shi, Y.; Duan, J.; Sun, Z. (2017-04)Air pollution has been a major environment-related health threat. Most of the studies on PM2.5 toxicity have verified on the cardiovascular system and endothelial cells. However, researches on PM2.5-induced myocardial-related ... -
Glycan Biomarkers for Rheumatoid Arthritis and Its Remission Status in Han Chinese Patients.
Sebastian, A.; Alzain, M. A.; Asweto, Collins O.; Song, H.; Cui, L.; Yu, X.; Ge, S.; Dong, H.; Rao, P.; Wang, H.; Fang, H.; Gao, Q.; Zhang, J.; He, D.; Guo, X.; Song, M.; Wang, Y.; Wang, W. (2016-06)Rheumatoid arthritis (RA), a systemic, chronic, and progressive inflammatory autoimmune disease, affects up to 1.0% of the world population doubling mortality rate of patients and is a major global health burden. Worrisomely, ... -
Integration of community health workers into health systems in developing countries: Opportunities and challenges
Asweto, Collins O.; Mohamed, Ali Alzain; Sebastian, Andrea; Rachel, Alexander; Wei, Wang (Systematic Review, 2016-01)Background: Developing countries have the potential to reach vulnerable and underserved populations marginalized by the country’s health care systems by way of community health workers (CHWs). It is imperative that health ... -
Low-dose combined exposure of nanoparticles and heavy metal compared with PM2.5 in human myocardial AC16 cells
Feng, L.; Yang, X.; Asweto, Collins O.; Wu, Jing; Zhang, Y; Hu, H.; Shi, Y.; Duan, Junchao; Sun, Z. (Springer, 2017-12)The co-exposure toxicity mechanism of ultrafine particles and pollutants on human cardiovascular system are still unclear. In this study, the combined effects of silica nanoparticles (SiNPs) and/or carbon black nanoparticles ... -
The Malaysian health care system: Ecology, plans, and reforms.
Sebastian, A.; Alzain, M. A.; Asweto, Collins O.; Mahara, G.; Guo, X.; Song, M.; Wang, Y.; Wang, W. (2016-01)Malaysia is on its way to achieving developed nation status in the next 4 years. Currently, Malaysia is on track for three Millennium Development Goals (MDG1, MDG4, and MDG7). The maternal mortality rate, infant mortality ... -
Maternal Autonomy, Distance to Health Care Facility and ANC Attendance Findings from Madiany Division of Siaya County, Kenya
Asweto, Collins O.; Aluoch, J. R.; Obonyo, C. O.; Ouma, J. O. (Science and Education Publishing, 2014-08)Half a million women die annually from pregnancy related causes. In Kenya, maternal mortality ratio (MMR) remains high in spite of great efforts to improve maternal health care. We studied some factors linked to maternity ...