| dc.description.abstract | Suboptimal health status (SHS) has been linked to cardiovascular risk factors, psychosocial stress, and unhealthy
lifestyle. These factors also contribute to the shortening of telomere length (TL). A case–control study
was conducted to examine the association between subjective health measures of SHS from the behavior
perspective and also objective measures of TL at molecular level. SHS (cases = 294) was matched by age, sex,
and body mass index with ideal health (controls = 294) using a propensity score matching method. Suboptimal
health status questionnaire-25 (SHSQ-25) was used in the community-based health survey. A quantitative
polymerase chain reaction was used to measure relative telomere length (RTL). Shorter RTL was found among
the SHS group compared to the ideal health group ( p < 0.05). SHS was almost four times likely to be in the first
quartile (odds ratio [OR] = 3.81; 95% confidence interval [CI] 2.21–6.56), almost thrice in second quartile
(OR = 2.84; 95% CI 1.65–4.90), and almost twice likely to be in the third quartile (OR = 1.71; 95% CI 1.00–
2.94) compared to the fourth quartile (the longest) of RTL after adjusting for socioeconomic, dietary intake,
anthropometric, blood pressure, and biochemistry variables ( p < 0.05). Notably, SHS score was negatively
correlated with RTL (r=-0.218, p < 0.05). Our study confirms an association between SHS and short RTL.
Combination of subjective (SHS) and objective (RTL) measures is a novel tool for health aging investigation.
Therefore, SHSQ-25 could be used as a screening tool for measuring biological aging in low-income countries
at community level where the expensive technique for RTL measurement is not applicable. | en_US |
