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dc.contributor.authorChiranjibi, Chhotaray
dc.contributor.authorYaoju, Tan
dc.contributor.authorMugweru, Julius
dc.contributor.authorIslam, Md Mahmudul
dc.contributor.authorHameed, H.M. Adnan
dc.contributor.authorWang, Shuai
dc.contributor.authorLu, Zhili
dc.contributor.authorWang, Changwei
dc.contributor.authorLi, Xinjie
dc.contributor.authorTan, Shouyong
dc.contributor.authorLiu, Jianxiong
dc.contributor.authorZhang, Tianyu
dc.date.accessioned2018-07-16T07:01:29Z
dc.date.available2018-07-16T07:01:29Z
dc.date.issued2018-07
dc.identifier.citationJournal of Genetics and Genomics 45 (2018) 281e297en_US
dc.identifier.urihttps://doi.org/10.1016/j.jgg.2018.06.003
dc.identifier.urihttp://hdl.handle.net/123456789/1923
dc.description.abstractMycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference (CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectMolecular genetic toolsen_US
dc.subjectGram-positiveen_US
dc.subjectRecombineeringen_US
dc.subjectDrug resistanceen_US
dc.titleAdvances in the development of molecular genetic tools for Mycobacterium tuberculosisen_US
dc.typeArticleen_US


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