dc.contributor.author | Yildiz, Yemliha | |
dc.contributor.author | Yaylim, Ilhan | |
dc.contributor.author | Ozkan, Nazli E. | |
dc.contributor.author | Arikan, Soykan | |
dc.contributor.author | Turan, Saime | |
dc.contributor.author | Kucucuk, Seden | |
dc.contributor.author | Coskunpinar, Ender | |
dc.contributor.author | Isbir, Turgay | |
dc.date.accessioned | 2016-10-25T06:54:57Z | |
dc.date.available | 2016-10-25T06:54:57Z | |
dc.date.issued | 2013-01 | |
dc.identifier.citation | American Journal of Molecular Biology, 2013, 3, 10-16 | en_US |
dc.identifier.uri | http://dx.doi.org/10.4236/ajmb.2013.31002 | |
dc.identifier.uri | http://hdl.handle.net/123456789/1028 | |
dc.description.abstract | Bax is an important protein involved in apoptotic process. Mutations of the Bax gene are known to af- fect protein expression and function. A promotor polymorphism G(-248)A in the 5’UTR of Bax gene may alter regulation of apoptosis in carcinogenesis. Our study was performed to test the association be- tween G(-248)A polymorphisms in the Bax gene and breast cancer risk and progression. G(-248)A poly- morphism was genotyped in a Turkish breast cancer, case-control population including 53 female cancer patients (mean age ± SD: 60.9 ± 11.9 years) and 82 controls (mean age ± SD: 57.2 ± 17.5 years) using PCR-RFLP analysis. Genotype and allele frequencies were assessed with the chi-square test. There was no difference in the distribution of Bax genotypes, and allele frequencies were G (87.7% versus 88.4%) and A (12.3% versus 11.6%) in the cancer patients and controls, respectively. Within the cancer group, the presence of a polymorphic Bax G(-248)A allele was not associated with clinico-pathological parameters such as advanced tumor stage, lymph node or distant metastasis. We present the first to report on Bax G(-248)A polymorphisms in breast cancer. Our re- sults suggest that Bax G(-248)A polymorphism do not modify individual susceptibility to invasive breast cancer in Turkish women. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Scientific Research Publishing | en_US |
dc.subject | Bcl-2 Associated-X-Protein | en_US |
dc.subject | SNP | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | PCR | en_US |
dc.subject | Susceptibility | en_US |
dc.subject | Carcinogenesis | en_US |
dc.title | Bax promoter G(-248)A polymorphism in a Turkish clinical breast cancer patients: A case-control study | en_US |
dc.type | Article | en_US |